Haematologica
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Haematologica, Vol 89, Issue 11, 1397-1399
Copyright © 2004 by Ferrata Storti Foundation

Letter

Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia

M Ritter, TD Kim, P Lisske, C Thiede, M Schaich, and A Neubauer

Reports on the prognostic impact of mutations in the RAS proto-oncogenes in patients with acute myeloid leukemia (AML) are conflicting. A peptide nucleic acid (PNA)-based technique was used on 232 AML samples to detect point mutations of the hotspots in N-RAS and K-RAS. No significant correlations between RAS mutations and clinical features, karyotype or FLT3 were found.


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