Haematologica
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Haematologica, Vol 89, Issue 11, 1401-1403
Copyright © 2004 by Ferrata Storti Foundation

Letter

Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas

F Gallardo, M Esteller, RM Pujol, C Costa, T Estrach, and O Servitje

p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.




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Copyright © 2004 by the Ferrata Storti Foundation.