Haematologica
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Haematologica, Vol 89, Issue 3, 365-366
Copyright © 2004 by Ferrata Storti Foundation

Clinical Trial

A randomized trial of dexamethasone before remission induction, in de novo childhood acute lymphoblastic leukemia

MA Lopez-Hernandez, M Alvarado, J De Diego, Borbolla-Escoboza JR, RM Jimenez, and E Trueba

We evaluated the impact of adding dexamethasone before chemotherapy in 95 children with de novo standard-risk acute lymphoblastic leukemia (ALL). The children were randomly divided into 2 groups: one group was given dexamethasone, the other was not. The initial characteristics and mean follow-up of both groups were similar. Day +14 blast percentage was significantly lower in the dexamethasone group. Disease-free survival at 40-months follow-up was better (almost significantly so) in the dexamethasone group.


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E. Laane, T. Panaretakis, K. Pokrovskaja, E. Buentke, M. Corcoran, S. Soderhall, M. Heyman, J. Mazur, B. Zhivotovsky, A. Porwit, et al.
Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members
Haematologica, November 1, 2007; 92(11): 1460 - 1469.
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