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Haematologica, Vol 91, Issue 1, 139-140
Copyright © 2006 by Ferrata Storti Foundation

Letter

Acute lymphoblastic leukemia in children with associated genetic conditions other than Down's syndrome. The AIEOP experience

O Ziino, R Rondelli, C Micalizzi, M Luciani, V Conter, and M Arico

We retrospectively reviewed the databases of seven studies on acute lymphoblastic leukemia (ALL) by the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) to identify patients with associated genetic disease, other than Down's syndrome. Forty-two patients were reported to have associated genetic conditions that included beta-thalassemia (n=10), ataxia-telangiectasia (n=5), neurofibromatosis (n=3), Sotos syndrome (n=2) and other individual conditions. Patients with ataxia-telangiectasia, all with T-cell ALL, had a higher frequency of adverse events.


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F. Tucci and M. Arico
Treatment of pediatric acute lymphoblastic leukemia
Haematologica, August 1, 2008; 93(8): 1124 - 1128.
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