Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rossi, D
Right arrow Articles by Gaidano, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rossi, D
Right arrow Articles by Gaidano, G
Haematologica, Vol 91, Issue 10, 1405-1409
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

D Rossi, E Berra, M Cerri, C Deambrogi, C Barbieri, S Franceschetti, M Lunghi, A Conconi, M Paulli, A Matolcsy, L Pasqualucci, D Capello, and G Gaidano

Division of Hematology, Department of Clinical and Experimental Medicine & IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy. rossidav@med.unipmn.it

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.


This article has been cited by other articles:


Home page
 haematolHome page
E. Gagyi, Z. Balogh, C. Bodor, B. Timar, L. Reiniger, L. Deak, J. Csomor, B. Csernus, A. Szepesi, and A. Matolcsy
Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression
Haematologica, December 1, 2008; 93(12): 1822 - 1828.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
D. Rossi, A. Zucchetto, F. M. Rossi, D. Capello, M. Cerri, C. Deambrogi, S. Cresta, S. Rasi, L. De Paoli, C. L. Bodoni, et al.
CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
Haematologica, October 1, 2008; 93(10): 1575 - 1579.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. L. Duquette, M. D. Huber, and N. Maizels
G-Rich Proto-Oncogenes Are Targeted for Genomic Instability in B-Cell Lymphomas
Cancer Res., March 15, 2007; 67(6): 2586 - 2594.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2006 by the Ferrata Storti Foundation.