Haematologica
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Haematologica, Vol 91, Issue 12, 1722-1723
Copyright © 2006 by Ferrata Storti Foundation

Clinical Trial, Phase II

Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma

KL Wu, M Beksac, J van Droogenbroeck, S Amadori, S Zweegman, and P Sonneveld

Arsenic trioxide induces growth inhibition and apoptosis in multiple myeloma cell lines. Reducing glutathione by ascorbic acid may enhance the efficacy of arsenic trioxide. Here we report the results of an international multi-center study of arsenic trioxide in combination with ascorbic acid and dexamethasone as treatment for patients with advanced multiple myeloma.


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