10 March 2010

Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood T cells

Anita Q. Gomes, Daniel V. Correia, Ana R. Grosso, Telma Lança, Cristina Ferreira, João F. Lacerda, João T. Barata, Maria Gomes da Silva, and Bruno Silva-Santos
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.020602 [Abstract] [PDF]  

Evaluation of the (R)VAD+C regimen for the treatment of newly diagnosed Mantle Cell Lymphoma. Combined results of two prospective phase II trials from the French GOELAMS group

Rémy Gressin, Sylvie Caulet-Maugendre, Eric Deconinck, Olivier Tournilhac, Emmanuel Gyan, Marie Pierre Moles, Abderrazak El Yamani, Jerome Cornillon, Jean François Rossi, Steven Le Gouill, Gérard Lepeu, Ghandi Damaj, Philippe Solal Celigny, Hervé Maisonneuve, Bernadette Corront, Jean Pierre Vilque, Philippe Casassus, Thierry Lamy-de-La-Chapelle, Marc Colonna, Philippe Colombat, and for the French GOELAMS group
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.011759 [Abstract] [PDF]  

Changes in MR bone marrow angiogenesis on day 7 after induction chemotherapy can predict outcome of acute myeloid leukemia

Hsin-An Hou, Tiffany Ting-Fang Shih, Chieh-Yu Liu, Bang-Bin Chen, Jih-Luh Tang, Ming Yao, Shang-Yi Huang, Wen-Chien Chou, Chao-Yu Hsu, and Hwei-Fang Tien
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.019364 [Abstract] [PDF]  

Extracranial internal carotid arterial disease in children with sickle cell anemia

Colin R. Deane, David Goss, Jack Bartram, Keith R.E. Pohl, Susan E. Height, Naomi Sibtain, Jozef Jarosz, Swee Lay Thein, and David C. Rees
Haematologica published March 10, 2010 as doi:10.3324/haematol.2010.022624 [Abstract] [PDF]  

Lipid rafts-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages

Anne Auriac, Alexandra Willemetz, and François Canonne-Hergaux
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.019992 [Abstract] [PDF]  

Hydroxyurea induced oscillations in twelve patients with polycythemia vera

Jan Tauscher, Fabian Siegel, and Petro E. Petrides
Haematologica published March 10, 2010 as doi:10.3324/haematol.2010.022178 [PDF]  

Early intervention during imatinib therapy in patients with newly diagnosed chronic-phase chronic myeloid leukemia. A study of the Spanish PETHEMA group

Francisco Cervantes, Pilar López-Garrido, María-Isabel Montero, Fermín Jonte, Jesús Martínez, Juan-Carlos Hernández-Boluda, María Calbacho, Anna Sureda, Gloria Pérez-Rus, José B. Nieto, Cristina Pérez-López, José Román-Gómez, Marcos González, Arturo Pereira, and Dolors Colomer
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.021154 [Abstract] [PDF]  

Digenic mutations in severe congenital neutropenia

Manuela Germeshausen, Cornelia Zeidler, Manfred Stuhrmann, Marina Lanciotti, Matthias Ballmaier, and Karl Welte
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.017665 [Abstract] [PDF]  

Combining chromosomal aberrations t(4;14) and del(17p13) with ISS allows a stratification of myeloma patients undergoing autologous stem cell transplantation

Kai Neben, Anna Jauch, Uta Bertsch, Christiane Heiss, Thomas Hielscher, Anja Seckinger, Tina Mors, Nadine Zoe Müller, Jens Hillengass, Marc S. Raab, Anthony D. Ho, Dirk Hose, and Hartmut Goldschmidt
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.016436 [Abstract] [PDF]  

The nature of peptides presented by an HLA class I low expression allele

Jan Hinrichs, Daniel Föll, Christina Bade-Döding, Trevor Huyton, Rainer Blasczyk, and Britta Eiz-Vesper
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.016089 [Abstract] [PDF]  

Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features

George Kanellis, Manuela Mollejo, Santiago Montes-Moreno, Socorro-María Rodriguez-Pinilla, Juan C Cigudosa, Patricia Algara, Carlos Montalban, Estela Matutes, Andrew Wotherspoon, and Miguel A Piris
Haematologica published March 10, 2010 as doi:10.3324/haematol.2009.013714 [Abstract] [PDF]  

23 February 2010

No association between myeloproliferative neoplasms and the Crohn’s disease-associated STAT3 predisposition SNP rs744166

Amy V. Jones and Nicholas C.P. Cross
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.023390 [PDF]  

P39/Tsugane cells are a false cell line contaminated with HL-60 cells and are not suitable for mechanistic studies in myelodysplastic syndromes

David P. Steensma
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.022988 [PDF]  

Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (mutations Chartres 1 and 2)

Emile van den Akker, Timothy J. Satchwell, Stephanie Pellegrin, Joanna F. Flatt, Michel Maigre, Geoff Daniels, Jean Delaunay, Lesley J. Bruce, and Ashley M. Toye
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.021063 [Abstract] [PDF]  

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, and Martina U. Muckenthaler
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.020123 [Abstract] [PDF]  

Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function

Vyatautas Ivaskevicius, Arijit Biswas, Carville Bevans, Verena Schroeder, Hans Peter Kohler, Hannelore Rott, Susan Halimeh, Petro E. Petrides, Harald Lenk, Manuele Krause, Bruno Miterski, Ursula Harbrecht, and Johannes Oldenburg
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.017210 [Abstract] [PDF]  

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

Fabrizio Vianello, Federica Villanova, Veronica Tisato, Stefania Lymperi, Ka-Kei Ho, Ana R. Gomes, David Marin, Dominique Bonnet, Jane Apperley, Eric W.-F. Lam, and Francesco Dazzi
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.017178 [Abstract] [PDF]  

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties

Selim Kuçi, Zyrafete Kuçi, Hermann Kreyenberg, Erika Deak, Kathrin Pütsch, Sabine Huenecke, Chandrasekhar Amara, Stefanie Koller, Eva Rettinger, Manuel Grez, Ulrike Koehl, Hatixhe Latifi-Pupovci, Reinhard Henschler, Torsten Tonn, Dorothee von Laer, Thomas Klingebiel, and Peter Bader
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.015065 [Abstract] [PDF]  

Relationship between minimal residual disease measured by multiparametric flow cytometry prior to allogeneic hematopoietic stem cell transplantation and outcome in children with acute lymphoblastic leukemia

Izaskun Elorza, Carlos Palacio, José Luis Dapena, Laura Gallur, José Sánchez de Toledo, and Cristina Díaz de Heredia
Haematologica published February 23, 2010 as doi:10.3324/haematol.2009.010843 [PDF]  

The integrin 9β1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation

Thomas D. Schreiber, Carolin Steinl, Mike Essl, Harald Abele, Konstanze Geiger, Claudia A. Müller, Wilhelm K. Aicher, and Gerd Klein
Haematologica published February 23, 2010 as doi:10.3324/haematol.006072 [PDF]  

9 February 2010

Reconstitution of NK cell receptors influences NK activity and relapse rate after haploidentical transplantation of T and B cell depleted grafts in children

Matthias M. Pfeiffer, Tobias Feuchtinger, Heiko-Manuel Teltschik, Michael Schumm, Ingo Müller, Rupert Handgretinger, and Peter Lang
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.021121 [Abstract] [PDF]  

Impact of the type of the BCR-ABL fusion transcript on the molecular response in pediatric patients with chronic myeloid leukemia

Meinolf Suttorp, Christian Thiede, Josephine T. Tauer, Ursula Range, Brigitte Schlegelberger, and Nils von Neuhoff
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.019224 [PDF]  

Thromboembolic events among adult patients with primary immune thrombocytopenia (ITP) in the United Kingdom General Practice Research Database

Ameet Sarpatwari, Dimitri Bennett, John W. Logie, Amit Shukla, Kathleen J. Beach, Adrian Newland, Simon Sanderson, and Drew Provan
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.018390 [Abstract] [PDF]  

PIM serine/threonine kinases in pathogenesis and therapy of hematological malignancies and solid cancers

Laurent Brault, Christelle Gasser, Franz Bracher, Kilian Huber, Stefan Knapp, and Jürg Schwaller
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.017079 [Abstract] [PDF]  

Prognosis of children with mixed phenotype acute leukemia treated in accordance with consistent immunophenotypic criteria

Ester Mejstrikova, Jana Volejnikova, Eva Fronkova, Katerina Zdrahalova, Tomas Kalina, Jaroslav Sterba, Yahia Jabali, Vladimir Mihal, Bohumir Blazek, Zdena Cerna, Daniela Prochazkova, Jiri Hak, Zuzana Zemanova, Marie Jarosova, Alexandra Oltova, Petr Sedlacek, Jiri Schwarz, Jan Zuna, Jan Trka, Jan Stary, and Ondrej Hrusak
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.014506 [Abstract] [PDF]  

The Southern French registry of genetic hemochromatosis: a tool for determination of clinical prevalence of the disorder and genotype penetrance

Patricia Aguilar-Martinez, Michael Bismuth, François Blanc, Pierre Blanc, Severine Cunat, Olivier Dereure, Pierre Dujols, Muriel Giansily-Blaizot, Christian Jorgensen, Amadou Konate, Dominique Larrey, Alain Le Quellec, Thibault Mura, Isabelle Raingeard, Jeanne Ramos, Eric Renard, Florence Rousseau, Jean-François Schved, and Marie-Christine Picot
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.014431 [Abstract] [PDF]  

Outcome after relapse of acute lymphoblastic leukemia (ALL) in adult patients included in four consecutive risk-adapted trials from the PETHEMA Study Group

Albert Oriol, Susana Vives, Jesús-María Hernández-Rivas, Mar Tormo, Inmaculada Heras, Concepción Rivas, Concepción Bethencourt, Federico Moscardó, Javier Bueno, Carlos Grande, Eloy del Potro, Ramon Guardia, Salut Brunet, Juan Bergua, Teresa Bernal, Maria-José Moreno, Carlota Calvo, Pilar Bastida, Evarist Feliu, Josep-Maria Ribera, and for the Programa Español de Tratamiento en Hematologia (PETHEMA) Group
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.014274 [Abstract] [PDF]  

Low levels of monoclonal small B-cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type

Anne M. Tierens, Harald Holte, Abdirashid Warsame, Ida M. Ikonomou, Junbai Wang, Wing C. Chan, and Jan Delabie
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.014100 [Abstract] [PDF]  

CXCL12-induced chemotaxis is impaired in T cells from ZAP-70^- chronic lymphocytic leukemia patients

Mercedes Borge, Paula Romina Nannini, Jeremías Gastón Galletti, Pablo Elías Morande, Julio Sánchez Ávalos, Raimundo Fernando Bezares, Mirta Giordano, and Romina Gamberale
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.013995 [Abstract] [PDF]  

High dose imatinib improves cytogenetic and molecular remissions in pretreated Ph⁺/BCR-ABL⁺ CML chronic phase patients: first results from the randomized CELSG Phase III CML 11 "ISTAHIT" Study

Andreas L. Petzer, Dominik Wolf, Dominic Fong, Thomas Lion, Irina Dyagil, Zvenyslava Masliak, Andrija Bogdanovic, Laimonas Griskevicius, Sandra Lejniece, Stefan Goranov, Liana Gercheva, Aleksandar Stojanovic, Dontcho Peytchev, Nikolay Tzvetkov, Rasa Griniute, Radka Oucheva, Hanno Ulmer, Marthin Kwakkelstein, Francesca Rancati, and Guenther Gastl
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.013979 [Abstract] [PDF]  

The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) induces apoptosis, downregulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells

Basile Stamatopoulos, Nathalie Meuleman, Cécile De Bruyn, Alain Delforge, Dominique Bron, and Laurence Lagneaux
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.013847 [Abstract] [PDF]  

Hematopoietic stem cells in coculture with mesenchymal stromal cells - modelling the niche compartments in vitro

Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, and Rainer Ordemann
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.010736 [Abstract] [PDF]  

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

Anita Hill, Russell P Rother, Louise Arnold, Richard Kelly, Matthew J Cullen, Stephen J Richards, and Peter Hillmen
Haematologica published February 9, 2010 as doi:10.3324/haematol.2009.007229 [Abstract] [PDF]  

4 February 2010

Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, and Andre J. van der Ven
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.019331 [Abstract] [PDF]  

Long-term immune deficiency after allogeneic stem cell transplantation: B cell deficiency is associated with late infections

Elise Corre, Maryvonnick Carmagnat, Marc Busson, Regis Peffault de Latour, Marie Robin, Patricia Ribaud, Antoine Toubert, Claire Rabian, and Gerard Socié
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.018853 [Abstract] [PDF]  

Long FLT3 internal tandem duplications and reduced PML-RAR expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients.

María Carmen Chillón, Carlos Santamaría, Ramón García-Sanz, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, Luis Marín, María Dolores Caballero, María Belén Vidriales, Fernando Ramos, Teresa Bernal, Joaquín Díaz-Mediavilla, Alfonso García de Coca, María Jesús Peñarrubia, José Antonio Queizán, Pilar Giraldo, Jesús F. San Miguel, and Marcos González
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.015073 [Abstract] [PDF]  

Sex differences in the JAK2^V617F allele burden in the chronic myeloproliferative disorders

Brady Stein, Donna Williams, Nae-Yuh Wang, Ophelia Rogers, Mary Ann Isaacs, Naveen Pemmaraju, Jerry Spivak, and Alison Moliterno
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.014407 [Abstract] [PDF]  

Vorinostat interferes with the signaling transduction pathway of T cell receptor and synergizes with PI3K inhibitors in cutaneous T-cell lymphoma

Magdalena B. Wozniak, Raquel Villuendas, James R. Bischoff, Carmen Blanco-Aparicio, Juan F. Martínez Leal, Paloma de La Cueva, Mª Elena Rodriguez, Beatriz Herreros, Daniel Martin-Perez, Maria I. Longo, Marta Herrera, Miguel Á. Piris, and Pablo L Ortiz-Romero
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.013870 [Abstract] [PDF]  

A phase 1 multidose study of dacetuzumab (SGN-40; humanized anti-CD40 mAb) in patients with multiple myeloma

Mohamad Hussein, James R. Berenson, Ruben Niesvizky, Nikhil Munshi, Jeffrey Matous, Ronald Sobecks, Kate Harrop, Jonathan G. Drachman, and Nancy Whiting
Haematologica published February 4, 2010 as doi:10.3324/haematol.2009.008003 [Abstract] [PDF]  

27 January 2010

Prognostic relevance of CD20 in adult B-cell precursor acute lymphoblastic leukemia

Hong Chang, Allan Jiang, and Joseph Brandwein
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.021089 [PDF]  

Surveillance investigations after high-dose therapy with stem cell rescue for recurrent follicular lymphoma have no impact on management

Marco Gerlinger, Ama Z.S. Rohatiner, Janet Matthews, Andrew Davies, T. Andrew Lister, and Silvia Montoto
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.020115 [Abstract] [PDF]  

Reduced intensity conditioning HLA identical sibling donor allogeneic stem cell transplantation for patients with follicular lymphoma: long-term follow-up from two prospective multicenter trials

José Luis Piñana, Rodrigo Martino, Jorge Gayoso, Anna Sureda, Javier de la Serna, Jose Luis Díez-Martín, Lourdes Vazquez, Reyes Arranz, José Francisco Tomás, Antonia Sampol, Carlos Solano, Julio Delgado, Jorge Sierra, Dolores Caballero, and for the GELTAMO Group
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.017608 [Abstract] [PDF]  

Screening for diverse PDGFRA or PDGFRB by fusion genes is facilitated by generic quantitative RT-PCR

Philipp Erben, Darko Gosenca, Martin C. Müller, Jelena Reinhard, Joannah Score, Francesco del Valle, Christoph Walz, Jürgen Mix, Georgia Metzgeroth, Thomas Ernst, Claudia Haferlach, Nicholas C.P. Cross, Andreas Hochhaus, and Andreas Reiter
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.016345 [Abstract] [PDF]  

Early reduction of WT1 transcripts during induction chemotherapy predicts for longer disease-free and overall survival in acute myeloid leukemia

Giacomo Gianfaldoni, Francesco Mannelli, Vanessa Ponziani, Giovanni Longo, Sara Bencini, Alberto Bosi, and Alessandro M. Vannucchi
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.011908 [Abstract] [PDF]  

The therapeutic response and clinical outcome of adults with ALL1(MLL)/AF4 fusion positive acute lymphoblastic leukemia according to the GIMEMA experience

Giuseppe Cimino, Natalia Cenfra, Loredana Elia, Simona Sica, Mario Luppi, Giovanna Meloni, Marco Vignetti, Francesca Paoloni, Robin Foà, and Franco Mandelli
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.009035 [Abstract] [PDF]  

Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation

Marije Bartels, Christian R. Geest, Marc Bierings, Miranda Buitenhuis, and Paul J. Coffer
Haematologica published January 27, 2010 as doi:10.3324/haematol.2009.008870 [Abstract] [PDF]  

15 January 2010

Long-term follow-up of essential thrombocythemia in young adults: treatment strategies, major thrombotic complications and pregnancies outcome - a study of 76 patients

Francesca Palandri, Nicola Polverelli, Emanuela Ottaviani, Fausto Castagnetti, Michele Baccarani, and Nicola Vianelli
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.019190 [PDF]  

Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138^– and CD138⁺ plasma cells

Anouk Caraux, Bernard Klein, Bruno Paiva, Caroline Bret, Alexander Schmitz, Gwenny M. Fuhler, Nico A. Bos, Hans E Johnsen, Alberto Orfao, Martin Perez-Andres, and for the Myeloma Stem Cell Network (MSCNET)
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.018689 [Abstract] [PDF]  

L718P mutation in the membrane-proximal cytoplasmic tail of β3 promotes abnormal IIbβ3 clustering and lipid microdomain coalescence, and associates with thrombasthenia-like phenotype

Asier Jayo, Isabel Conde, Pedro Lastres, Constantino Martínez, José Rivera, Vicente Vicente, and Consuelo González-Manchón
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.018572 [Abstract] [PDF]  

Allogeneic hematopoietic stem cell transplantation allows long-term complete remission and curability in high-risk Waldenström’s macroglobulinemia. Results of a retrospective analysis of the Société Française de Greffe de Moelle et de Thérapie Cellulaire

Alice Garnier, Marie Robin, Fabrice Larosa, Jean-Louis Golmard, Steven Le Gouill, Valérie Coiteux, Reza Tabrizi, Claude-Eric Bulabois, Victoria Cacheux, Mathieu Kuentz, Brigitte Dreyfus, Peter Dreger, Bernard Rio, Marie-Pierre Moles-Moreau, Karin Bilger, Jacques-Olivier Bay, Véronique Leblond, Didier Blaise, Olivier Tournilhac, and Nathalie Dhédin
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.017814 [Abstract] [PDF]  

Hematopoietic stem –and progenitor cells are differentially mobilized dependent on the the duration of Flt3-ligand administration

Evert-Jan F.M. de Kruijf, Henny Hagoort, Gerjo A. Velders, Willem E. Fibbe, and Melissa van Pel
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.016691 [Abstract] [PDF]  

Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

Dominique Helley, Régis Peffault de Latour, Raphaël Porcher, Celso Arrais Rodrigues, Isabelle Galy-Fauroux, Jeanne Matheron, Arnaud Duval, Jean-François Schved, Anne-Marie Fischer, Gérard Socié, and on behalf of the French Society of Hematology
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.016121 [Abstract] [PDF]  

High dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and multiple myeloma (MM)

Jochen Greiner, Anita Schmitt, Krzysztof Giannopoulos, Markus T. Rojewski, Marlies Götz, Isabel Funk, Mark Ringhoffer, Donald Bunjes, Susanne Hofmann, Gerd Ritter, Hartmut Döhner, and Michael Schmitt
Haematologica published January 15, 2010 as doi:10.3324/haematol.2009.014704 [Abstract] [PDF]  

6 January 2010

Autoimmunity and the risk of myeloproliferative neoplasms

Sigurdur Yngvi Kristinsson, Ola Landgren, Jan Samuelsson, Magnus Björkholm, and Lynn R. Goldin
Haematologica published January 6, 2010 as doi:10.3324/haematol.2009.020412 [Abstract] [PDF]  

Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism

Frederikus Klok, Klaas van Kralingen, Arie van Dijk, Fenna Heyning, Hubert Vliegen, and Menno Huisman
Haematologica published January 6, 2010 as doi:10.3324/haematol.2009.018960 [Abstract] [PDF]  

Similar favorable outcome of pegfilgrastim overdose in patients with different age and underlying disease

Carlo Dufour, Barbara Cappelli, Michaela Calvillo, Francesca Fioredda, Rossella Tonelli, and Roberto Crocchiolo
Haematologica published January 6, 2010 as doi:10.3324/haematol.2009.018333 [PDF]  

Melphalan, prednisone, thalidomide and defibrotide in relapsed/refractory multiple myeloma: results of multicenter phase I/II trial

Antonio Palumbo, Alessandra Larocca, Mariella Genuardi, Katarzyna Kotwica, Francesca Gay, Davide Rossi, Giulia Benevolo, Valeria Magarotto, Federica Cavallo, Sara Bringhen, Cecilia Rus, Luciano Masini, Massimo Iacobelli, Gianluca Gaidano, Constantine Mitsiades, Kenneth Anderson, Mario Boccadoro, Paul Richardson, and for the Italian Multiple Myeloma Network, GIMEMA
Haematologica published January 6, 2010 as doi:10.3324/haematol.2009.017913 [Abstract] [PDF]  

Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

Katharina Schallmoser, Christina Bartmann, Eva Rohde, Simone Bork, Christian Guelly, Anna C. Obenauf, Andreas Reinisch, Patrick Horn, Anthony D. Ho, Dirk Strunk, and Wolfgang Wagner
Haematologica published January 6, 2010 as doi:10.3324/haematol.2009.011692 [Abstract] [PDF]  

16 December 2009

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly

Meina Zhao, Hirokazu Kanegane, Kazutaka Ouchi, Toshihiko Imamura, Sylvain Latour, and Toshio Miyawaki
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.018010 [PDF]  

Early hemorrhagic death before starting therapy in acute promyelocytic leukemia: association with high WBC count, late diagnosis and delayed treatment initiation

Massimo Breccia, Roberto Latagliata, Laura Cannella, Clara Minotti, Giovanna Meloni, and Francesco Lo-Coco
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.017962 [PDF]  

ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes

Marie-Marcelle Trinh-Trang-Tan, Camilo Vilela-Lamego, Julien Picot, Marie-Paule Wautier, and Jean-Pierre Cartron
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.017392 [Abstract] [PDF]  

The UNC13D gene is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis

Hoi-Soo Yoon, Hee-Jin Kim, Keon-Hee Yoo, Ki-Woong Sung, Hong-Hoe Koo, Hyoung-Jin Kang, Hee-Young Shin, Hyo-Seop Ahn, Ji-Yoon Kim, Young-Tak Lim, Keun-Wook Bae, Ki-O Lee, Ji-Sook Shin, Seung-Tae Lee, Hae-Sun Chung, Sun-Hee Kim, Chan-Jeong Park, Hyun-Sook Chi, Ho-Joon Im, and Jong-Jin Seo
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.016949 [Abstract] [PDF]  

Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia

Wendy Deenik, Jeroen J.W.M. Janssen, Bronno van der Holt, Gregor E.G. Verhoef, Willem M. Smit, Marie José Kersten, Simon M.G.J. Daenen, Leo F. Verdonck, Augustin Ferrant, Anton V.M.B. Schattenberg, Pieter Sonneveld, Marinus van Marwijk Kooy, Shulamit Wittebol, Roelof Willemze, Pierre W. Wijermans, H. Berna Beverloo, Bob Löwenberg, Peter J.M. Valk, Gert J. Ossenkoppele, and Jan J. Cornelissen
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.016766 [Abstract] [PDF]  

Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia

Mariël L. te Winkel, Robert D. van Beek, Sabine M.P.F. de Muinck Keizer-Schrama, André G. Uitterlinden, Wim C.J. Hop, Rob Pieters, and Marry M. van den Heuvel-Eibrink
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.016303 [Abstract] [PDF]  

Can antigen-specific regulatory T cells protect against graft vs. host disease and spare anti-malignancy alloresponse?

Joseph Pidala and Claudio Anasetti
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.015818 [Abstract] [PDF]  

A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease

Pathrapol Lithanatudom, Amporn Leecharoenkiat, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, and Duncan R. Smith
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.015701 [Abstract] [PDF]  

The HIF-2 transcription factor is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

Sally K. Martin, Peter Diamond, Sharon A. Williams, Luen Bik To, Daniel J. Peet, Nobutaka Fujii, Stan Gronthos, Adrian L. Harris, and Andrew C.W. Zannettino
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.015628 [Abstract] [PDF]  

Constitutional mismatch repair deficiency and childhood leukemia/lymphoma – report on a novel biallelic MSH6 mutation

Tim Ripperger, Carmela Beger, Nils Rahner, Karl W. Sykora, Clemens L. Bockmeyer, Ulrich Lehmann, Hans H. Kreipe, and Brigitte Schlegelberger
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.015503 [Abstract] [PDF]  

Myelin protein zero is naturally processed in IgM MGUS B cells: aberrant triggering of patient T cells

Eva Hellqvist, Maria Kvarnström, Anita Söderberg, Magnus Vrethem, Jan Ernerudh, and Anders Rosén
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.015123 [Abstract] [PDF]  

MOLECULAR ANALYSIS OF FORTY TWO CDA II PATIENTS: NEW MUTATIONS IN THE SEC23B GENE. SEARCH FOR A GENOTYPE-PHENOTYPE RELATIONSHIP

Achille Iolascon, Roberta Russo, Maria Rosaria Esposito, Roberta Asci, Carmelo Piscopo, Silverio Perrotta, Madeleine Fénéant-Thibault, Loïc Garçon, and Jean Delaunay
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.014985 [Abstract] [PDF]  

Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia

Theo D. Kim, Seval Türkmen, Michaela Schwarz, Gökben Koca, Hendrik Nogai, Christiane Bommer, Bernd Dörken, Peter Daniel, and Philipp le Coutre
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.014712 [Abstract] [PDF]  

Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells

Djordje Atanackovic, York Hildebrandt, Adam Jadczak, Yanran Cao, Tim Luetkens, Sabrina Meyer, Sebastian Kobold, Katrin Bartels, Caroline Pabst, Nesrine Lajmi, Maja Gordic, Tanja Stahl, Axel R. Zander, Carsten Bokemeyer, and Nicolaus Kröger
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.014464 [Abstract] [PDF]  

Daily practice management of myelodysplastic syndromes in France: Results of a one-week cross-sectional study in 907 patients by the Groupe Francophone des Myélodysplasies.

C Kelaidi, A Stamatoullas, O Beyne-Rauzy, E Raffoux, B Quesnel, A Guerci, F Dreyfus, S Brechignac, C Berthou, T Prebet, Y Hicheri, M Hacini, J Delaunay, MP Gourin, JM Camo, H Zerazhi, AL Taksin, L Legros, B Choufi, P Fenaux, and on behalf of the Groupe Francophone des Myélodysplasies (GFM)
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.014357 [Abstract] [PDF]  

C/EBPβ expression in ALK+ anaplastic large cell lymphomas (ALCL) is required for cell proliferation and is induced by the STAT3 signaling pathway

Natasa Anastasov, Irina Bonzheim, Martina Rudelius, Margit Klier, Therese Dau, Daniela Angermeier, Justus Duyster, Stefania Pittaluga, Falko Fend, Mark Raffeld, and Leticia Quintanilla-Martinez
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.014050 [Abstract] [PDF]  

High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations

Frank Stegelmann, Lars Bullinger, Martin Griesshammer, Karlheinz Holzmann, Marianne Habdank, Susanne Kuhn, Carmen Maile, Stefanie Schauer, Hartmut Döhner, and Konstanze Döhner
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.013623 [Abstract] [PDF]  

Mouse Mesenchymal Stem Cells Can Support Human Hemopoiesis both In Vitro and In Vivo: Crucial Role of Neural Cell Adhesion Molecule (NCAM)

Xiaoli Wang, Hiroko Hisha, Tomomi Mizokami, Wenhao Cui, Yunze Cui, Aiping Shi, Changye Song, Satoshi Okazaki, Qing Li, Wei Feng, Junko Kato, and Susumu Ikehara
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.013151 [Abstract] [PDF]  

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

Ana Silva, Patrícia Y. Jotta, André B. Silveira, Daniel Ribeiro, Silvia R. Brandalise, J. Andrés Yunes, and João T. Barata
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.011999 [Abstract] [PDF]  

Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?

Göran Mattsson, Susan H. Turner, Jacqueline Cordell, David J. P. Ferguson, Anna Schuh, Lizz F. Grimwade, Anthony J. Bench, Olga K. Weinberg, Teresa Marafioti, Tracy I. George, Daniel A. Arber, Wendy N. Erber, and David Y. Mason
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.011817 [Abstract] [PDF]  

CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathologic, cytogenetic and molecular study of 24 cases

Lucile Baseggio, Alexandra Traverse-Glehen, Florence Petinataud, Evelyne Callet-Bauchu, Françoise Berger, Martine Ffrench, Chantal Marie Couris, Catherine Thieblemont, Dominique Morel, Bertrand Coiffier, Gilles Salles, and Pascale Felman
Haematologica published December 16, 2009 as doi:10.3324/haematol.2009.011049 [Abstract] [PDF]  

8 December 2009

The -582A>G variant of the HAMP promoter is not associated with high serum ferritin levels in normal subjects

Francesca Bruno, Sara Bonalumi, Clara Camaschella, Maurizio Ferrari, and Laura Cremonesi
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.018986 [PDF]  

Complications and treatment of patients with β-thalassemia in France: results of the national registry

Isabelle Thuret, Corinne Pondarré, Anderson Loundou, Dominique Steschenko, Robert Girot, Dora Bachir, Christian Rose, Vincent Barlogis, Jean Donadieu, Mariane de Montalembert, Isabelle Hagege, Brigitte Pegourie, Claire Berger, Marguerite Micheau, Françoise Bernaudin, Thierry Leblanc, Laurence Lutz, Frédéric Galactéros, Marie-Claude Siméoni, and Catherine Badens
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.018051 [Abstract] [PDF]  

HAMP promoter mutation nc.-153C>T in non p.C282Y homozygous patients with iron overload

Patricia Aguilar-Martinez, Muriel Giansily-Blaizot, Michael Bismuth, Séverine Cunat, Hélène Igual, and Jean François Schved
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.018028 [PDF]  

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

Richard van Wijk, Scott Sutherland, Annet C.W. Van Wesel, Eric G. Huizinga, Melanie J. Percy, Marc Bierings, and Frank S. Lee
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.017582 [Abstract] [PDF]  

Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

Stella Santarone, Andrea Bacigalupo, Antonio M. Risitano, Elena Tagliaferri, Erminia Di Bartolomeo, Anna Paola Iori, Alessandro Rambaldi, Emanuele Angelucci, Alessandra Spagnoli, Federico Papineschi, Stefania Tamiazzo, Marta Di Nicola, and Paolo Di Bartolomeo
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.017269 [Abstract] [PDF]  

Different risk of deep vein thrombosis and pulmonary embolism in carriers with factor V Leiden compared with non-carriers, but not in other thrombophilic defects. Results from a large retrospective family cohort study

Anja B.U. Mäkelburg, Nic J.G.M. Veeger, Saskia Middeldorp, Karly Hamulyák, Martin H. Prins, Harry R. Büller, and Willem M. Lijfering
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.017061 [Abstract] [PDF]  

Homozygous deletion of HFE is the common cause of hemochromatosis in Sardinia

Gérald Le Gac, Rita Congiu, Isabelle Gourlaouen, Milena Cau, Claude Férec, and Maria Antonietta Melis
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.016816 [Abstract] [PDF]  

Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells

Tom Lenaerts, Jorge M. Pacheco, Arne Traulsen, and David Dingli
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.015271 [Abstract] [PDF]  

Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region

Wen-Yan He, Yu Lan, Hui-Yu Yao, Zhuan Li, Xiao-Yan Wang, Xiu-Sen Li, Ji-Yan Zhang, Yu Zhang, Bing Liu, and Ning Mao
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.014241 [Abstract] [PDF]  

Prophylaxis of invasive aspergillosis with voriconazole or caspofungin in patients with acute leukemia during building works

Amélie Chabrol, Lise Cuzin, Françoise Huguet, Muriel Alvarez, Xavier Verdeil, Marie Denise Linas, Sophie Cassaing, Jacques Giron, Laurent Tetu, Michel Attal, and Christian Récher
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.012633 [Abstract] [PDF]  

A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia

Theis H. Terwey, Philipp G. Hemmati, Peter Martus, Ekkehart Dietz, Lam G. Vuong, Gero Massenkeil, Bernd Dörken, and Renate Arnold
Haematologica published December 8, 2009 as doi:10.3324/haematol.2009.011809 [Abstract] [PDF]  

30 November 2009

Enhanced sensitivity of flow cytometry for routine assessment of minimal residual disease

Esther Domingo, Cristina Moreno, Alfonso Sánchez-Ibarrola, Carlos Panizo, José Antonio Páramo, and Juana Merino
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.018911 [PDF]  

A novel telomeric (~285 kb) -thalassemia deletion leading to a phenotypically unusual HbH disease

Philippe Joly, Philippe Lacan, Audrey Labalme, Elodie Bonhomme, Damien Sanlaville, and Alain Francina
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.018663 [PDF]  

Diagnosis of platelet-type von Willebrand disease by flow cytometry

Silvia Giannini, Luca Cecchetti, Anna Maria Mezzasoma, and Paolo Gresele
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.015990 [Abstract] [PDF]  

Factors Predicting Long Term Survival After T Cell Depleted Reduced Intensity Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

Charles Craddock, Sandeep Nagra, Andrew Peniket, Cassandra Brookes, Laura Buckley, Emmanouil Nikolousis, Nick Duncan, Sudhir Tauro, John Yin, Effie Liakopoulou, Panos Kottaridis, John Snowden, Donald Milligan, Gordon Cook, Eleni Tholouli, Tim Littlewood, Karl Peggs, Paresh Vyas, Fiona Clark, Mark Cook, Stephen MacKinnon, and Nigel Russell
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.013920 [Abstract] [PDF]  

Role of the PI3K/AKT and mTOR signalling pathways in acute myeloid leukemia

Sophie Park, Nicolas Chapuis, Jérôme Tamburini, Valérie Bardet, Pascale Cornillet-Lefebvre, Lise Willems, Alexa Green, Patrick Mayeux, Catherine Lacombe, and Didier Bouscary
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.013797 [Abstract] [PDF]  

PREGNANCY AND DELIVERY IN WOMEN WITH VON WILLEBRAND DISEASE AND DIFFERENT VON WILLEBRAND FACTOR MUTATIONS

Giancarlo Castaman, Alberto Tosetto, and Francesco Rodeghiero
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.011239 [Abstract] [PDF]  

In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

Enrique M. Ocio, David Vilanova, Peter Atadja, Patricia Maiso, Edvan Crusoe, Diego Fernández-Lázaro, Mercedes Garayoa, Laura San-Segundo, Teresa Hernández-Iglesias, Enrique de Álava, Wenlin Shao, Yung-Mae Yao, Atanasio Pandiella, and Jesús F. San-Miguel
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.015495 [Abstract] [PDF] [Ocio et al. Supplementary Appendix]  

Mutations of the Shwachman-Bodian-Diamond syndrome (SBDS) gene in patients presenting with refractory cytopenia – do we have to screen?

Axel Karow, Christian Flotho, Michaela Schneider, Manfred Fliegauf, Charlotte M. Niemeyer, and on behalf of the European Working Group of Myelodysplastic Syndromes in Childhood
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.015008 [PDF]  

Tailoring iron chelation by iron intake and serum ferritin: prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias

Maria Domenica Cappellini, John Porter, Amal El-Beshlawy, Chi-Kong Li, John F. Seymour, Mohsen Elalfy, Norbert Gattermann, Stéphane Giraudier, Jong-Wook Lee, Lee Lee Chan, Kai-Hsin Lin, Christian Rose, Ali Taher, Swee Lay Thein, Vip Viprakasit, Dany Habr, Gabor Domokos, Bernard Roubert, Antonis Kattamis, and on behalf of the EPIC study investigators
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.014696 [Abstract] [PDF] [Cappellini et al. Supplementary Appendix]  

FLOW MRD monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34⁺CD38^lowCD19⁺ in B lineage childhoood acute lymphoblastic leukemia

Kerrie Wilson, Marian Case, Lynne Minto, Simon Bailey, Nick Bown, Jenny Jesson, Sarah Lawson, Josef Vormoor, and Julie Irving
Haematologica published November 30, 2009 as doi:10.3324/haematol.2009.011726 [Abstract] [PDF] [Wilson et al. Supplementary Appendix]  

22 October 2009

invasive aspergillosis in patients with acute myeloid leukemia: SEIFEM-2008 registry study

Livio Pagano, Morena Caira, Anna Candoni, Massimo Offidani, Bruno Martino, Giorgina Specchia, Domenico Pastore, Marta Stanzani, Chiara Cattaneo, Rosa Fanci, Cecilia Caramatti, Fausto Rossini, Mario Luppi, Leonardo Potenza, Felicetto Ferrara, Maria Enza Mitra, Rafaela Maria Fadda, Rosangela Invernizzi, Teresa Aloisi, Marco Picardi, Alessandro Bonini, Adriana Vacca, Anna Chierichini, Lorella Melillo, Chiara de Waure, Luana Fianchi, Marta Riva, Giuseppe Leone, Franco Aversa, and Annamaria Nosari
Haematologica published October 22, 2009 as doi:10.3324/haematol.2009.012054 [Abstract] [PDF]  

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